NARROWBAND UVB THERAPY VS NARROWBAND UVB AND PIMECROLIMUS IN CHILDHOOD VITILIGO: A RANDOMISED CONTROLLED STUDY

Binodini Behera, Vivekanandh. K, Prasenjeet Mohanty, Bharati Sahu, Archana Jayakumar, Gaurav dash

Abstract


Background:Narrow-band ultraviolet B (NB-UVB) and pimecrolimus are proven safe options in childhood vitiligo. Aims:To compare efficacy of NB-UVB with pimecrolimus vs only NB-UVB in childhood vitiligo. Methods: Eighty patients were randomized into two groups and treated with NB-UVB in group A and NB-UVB with pimecrolimus in group B for 6 months. Tri-weekly radiation was started at 280 mJ/cm², with 10% increments for each subsequent treatment until minimal erythema dose was reached. Photodocumentation was done in each visit and follow-up was done for 6 months to detect any relapse. Results:Good to excellent response in the face and neck lesions was 95% in Group B vs 50%in Group A (p<0.05). There was no statistically significant difference in the repigmentation rate on other body areas. No significant side effects were observed in both groups. Conclusion:NB-UVB works better if combined with pimecrolimus 1% cream over face and neck lesions.

Keywords


narrowband UVB, pimecrolimus, childhood vitiligo

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